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. 2023 Jul 24;14(7):461. doi: 10.1038/s41419-023-05926-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A The GSEA enrichment plot showed cell cycle pathway is enriched in the chondrosarcoma (P < 0.01, NES = 1.88). B The heatmap representation of this subset of genes. C BioPlanet signal pathway enrichment analysis by using the downregulated genes in GANT-61 treatment. D Cell cycle and apoptosis analysis stained by propidium iodide in the isolated tumor cells of the two groups with flow cytometry. E The bar chart shows the percentage of cells in the cell cycle. F qPCR analysis for CDK1 and Cyclin A2 (**P < 0.01). G The bar graph showed a significant increase in apoptosis rate in GANT-61 treatment group (**P < 0.01). H qPCR analysis for Caspase3 (**P < 0.01). I Protein expression levels of CDK1, Cyclin A2, and cleaved-Caspase-3 were assessed using Western blot analysis.