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. 2023 Jul 24;14(7):461. doi: 10.1038/s41419-023-05926-6

Fig. 6. GANT-61 activated ULK1 and MAPK signaling pathway to regulate autophagy.

Fig. 6

A Isolated tumor cells were exposed to CQ (10 µM) or Rapa (100 nM) for 48 h. Then cell viability was tested using a CCK-8 assay (*P < 0.05, **P < 0.01). B Representative images of xenograft tumors in the GANT-61, GANT61 + CQ, and GANT61+Rapa groups. C Tumor volume growth curves were plotted per three days for one month for the above groups. (*P < 0.05, **P < 0.01). D Leading edge analysis to determine the most critical gene in autophagy. E The GSEA enrichment plot showed MAPK signal pathway is decreased in the chondrosarcoma (P < 0.01, NES = −1.61). F The heatmap representation of this subset of genes. G KEGG signal pathway enrichment analysis by using the upregulated genes in GANT-61 treatment. H The connections of autophagy and MAPK signal pathways in ConsensusPathDB datasets.