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. 2023 Jul 24;13:11950. doi: 10.1038/s41598-023-37300-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The value of the m5Cscore and clinical function in the meta-CRC cohort. (A) Survival time and survival status comparisons between the high- and low-m5Cscore groups (K-M method, P < 0.001, log-rank test). (B) The difference in the m5Cscore in the distinct CRC age groups (≤ 65 vs. > 65). (C) The difference in the m5Cscore in the distinct CRC stage groups (I + II vs. III + IV). (D) The difference in the m5Cscore in the distinct CRC outcome groups (alive vs. dead). (E) The distribution diagram of the m5Cscore in the distinct CRC stage groups. (F) The OS between the high- and low-m5Cscore groups in the age ≤ 65 group (687 samples) and (G) the age > 65 group (905 samples). (H–K) The OS between the high- and low-m5Cscore groups in I (202 samples), II (680 samples), III (575 samples) and IV (135 samples).