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. 2023 Jul 24;13:11950. doi: 10.1038/s41598-023-37300-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The TME landscapes and biological processes in the distinct m5Cscore groups. (A) The difference in the m5Cscore in the distinct m5C clusters using the Kruskal–Wallis test. (B) The difference in the m5Cscore in the distinct gene clusters. (C) The differential expression of each gene included in the immune activation-related gene signature between the m5Cscore high and low groups. (D) The differential expression of each gene included in the growth factor TGF-β/EMT pathway gene signature between the high and low m5Cscore groups. (E) The correlation between the m5Cscore and each TME-infiltrating cell type using Spearman analyses. The positive correlation is marked with red, and the negative correlation is marked with blue. The size of the circles represents the correlation coefficient (*P < 0.05). (F) Heatmap of the different immune cells that infiltrated the TME between the high and low m5Cscore groups. The clinical characteristics and CRC cohort distribution in the distinct m5Cscore groups. Each column represents patients, and each row represents individual immune cells. (G) Correlations between the m5Cscore and the known biological gene signatures using Spearman analyses. The positive correlation is marked with red, and the negative correlation is marked with blue. The size of the circles represents the correlation coefficient (*P < 0.05). (H) The different immune scores and three m5C clusters were compared and plotted. (I) Stromal score, (J) ESTIMATE score and (K) tumor purity between the high and low m5Cscore groups.