Table 2.
Noncoding RNAs that promote ferroptosis in cancer.
| ncRNAs | Targets | Model | Mechanism summary | Reference |
|---|---|---|---|---|
| miR-15a | GPX4 | LNCaP cell line | miR-15a promotes ferroptosis by inhibiting GPX4 expression. | [61] |
| miR-15a-3p | GPX4 | Patient’s tumor tissues; nude mice; HCT‐116, CaCo2, HT29, and KM12 cell lines | miR-15a-3p positively regulates ferroptosis by directly targeting GPX4, thereby inhibiting cancer cell proliferation, migration, and invasion. | [62] |
| miR-4715-3p | AURKA/ GPX4 | Patient’s tumor tissues; MKN45 and STKM2 cell lines | miR-4715-3p mediates decreased AURKA levels, and inhibition of AURKA or recombination of miR-4715-3p inhibits GPX4 and induces ferroptosis. | [63] |
| miR-324-3p | GPX4 | A549 cell line | miR-324-3p directly targets GPX4 to induce ferroptosis and reverse cisplatin resistance. | [64] |
| miR-302a-3p | FPN | A549, H358, H1299, and H1650 cell lines | miR-302a-3p increases ROS accumulation, induces ferroptosis, and inhibits cell growth by targeting FPN. | [65] |
| miR-214-3p | ATF4/GSH | nude mice; HepG2 and Hep3B cell lines | miR-214 directly targets ATF4, reduces GSH, enhances erastin-induced ferroptosis, and suppresses tumor growth. | [66] |
| lncPVT1 | miR-214-3p/GPX4 | Patient’s tumor tissues; nude mice; HepG2 and Huh7 cell lines | Depletion of lncPVT1 accelerates ferroptosis through the miR-214-3p/GPX4 axis. | [67] |
| SLC16A1-AS1 | miR-1433p/SLC7A11 | HK-2, 786-O, A498, and Caki-1 cell lines | lncRNA SLC16A1-AS1 induces ferroptosis and inhibits cell viability, proliferation, and migration through miR-143-3p/SLC7A11 signaling | [68] |
| LINC00618 | LSH/SLC7A11 | HL60, K562, MV4-11 and CCRF- CEM cell lines | LINC0618 interacts with LSH to affect the expression of SLC7A11 and trigger ferroptosis. | [69] |
| ARHGEF26-AS1 | miR-372-3p/ ADAM23/GPX4/SLC7A11 | Ec9706, TE-1, and EC109 cell lines | ARHGEF26-AS1 promotes ferroptosis by inhibiting SLC7A11 but inhibits cell growth via miR-372-3p. | [70] |
| P53RRA | G3BP1/P53 | A549, H358, and H522 cell lines | P53RRA induces ferroptosis and acts as a potential tumor suppressor by displacing p53 from the cytosolic G3BP1 complex. | [71] |
| MT1DP | miR-365a-3p/NRF2 | Patient’s tumor tissues; nude mice; A549 and H1299 cell lines | MT1DP sensitizes ferroptosis by upregulating MDA and ROS levels, and reducing GSH levels via miR-365a-3p/NRF2 axis. | [72] |
| circ0000190 | miR-382-5p/ ZNRF3 | Patient’s tumor tissues; AGS, KATO III, MKN1, and HGC27 cell lines | circ_0000190 sponges miR-382-5p, inhibits cell proliferation, and promotes erastin-induced ferroptosis by targeting ZNRF3. | [73] |
| circ0007142 | miR-874-3p | Patient’s tumor tissues; nude mice; HCT116, SW620, and SW480 cell lines | circ_0007142 serves as an miR-874-3p sponge to increase Fe2+ levels, activates ferroptosis, and suppresses cancer progression. | [74] |
| circGFRA1 | miR1228/AIFM2/GPX4 | Patient’s tumor tissues; nude mice; SKBR3 and BT474 cell lines | Silencing circGFRA1 downregulates GPX4 expression and enhances ferroptosis through the miR-1228/AIFM2 axis. | [75] |
| circLMO1 | miR-4291/ACSL4 | Patient’s tumor tissues; SiHa, HeLa, CaSki, and C33A cell lines | circLMO1 suppresses cervical cancer growth and metastasis by triggering miR-4291/ACSL4-mediated ferroptosis. | [76] |
| circ-IARS | ALKBH5 | HepG2, SMMC-7721, and Huh7 cell lines | circ-IARS increases MDA and Fe2+ levels and positively regulates ferroptosis through ALKBH5-mediated autophagy. | [77] |
ACSL4 acyl-CoA synthetase long-chain family member 4, ADAM23 disintegrin and metalloproteinase domain-containing protein 23, AIFM2 apoptosis-inducing factor mitochondria-associated 2, ALKBH5 AlkB homolog 5, ATF4 activating transcription factor 4, AURKA Aurora kinase A, circGFRA1 circular RNA glial cell line-derived neurotrophic factor family receptor alpha-1, circ-IARS circular RNA IARS, circLMO1 circular RNA LIM domain only 1, FPN ferroportin, GPX4 glutathione peroxidase 4, GSH glutathione, G3BP1 GTPase-activating protein-binding protein 1, LINC00618 long intergenic nonprotein-coding RNA 618, lncRNA long noncoding RNA, lncPVT1 long noncoding RNA plasmacytoma variant translocation 1, LSH lymphoid-specific helicase, MDA malondialdehyde, miR microRNA, NRF2 nuclear factor erythroid 2-related factor 2, P53RRA cytosolic p53-related lncRNA, ROS reactive oxygen species, SLC7A11 solute carrier family 7 member 11, ZNRF3 zinc and ring finger 3.