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. 2023 Jul 24;14(7):460. doi: 10.1038/s41419-023-05930-w

Table 3.

Synthetic and natural compounds regulating ferroptosis in cancer therapy.

Name Molecular structure Targets Models Tumor Reference Phase of clinical development
Sorafenib graphic file with name 41419_2023_5930_Taba_HTML.gif GPX4 and SLC7A11 Huh7, PLC/PRF5, PANC-1, BxPC-3, HCT116, and HT-29 cell lines Hepatocellular carcinoma; pancreatic adenocarcinoma; colon carcinoma [124, 130, 131] Approved
Cisplatin graphic file with name 41419_2023_5930_Tabb_HTML.gif GPX4 Nude mice; A549, NCI‐H460, and H1299 cell lines Lung cancer [132] Approved
Erastin graphic file with name 41419_2023_5930_Tabc_HTML.gif ROS and iron Xenograft models; DU145, PC3, 22Rv1, LNCaP, and NCI-H660 cell lines Prostate cancer [133] Preclinical
RSL3 graphic file with name 41419_2023_5930_Tabd_HTML.gif ROS and iron Xenograft models; DU145, PC3, 22Rv1, LNCaP, and NCI-H660 cell lines Prostate cancer [133] Preclinical
JQ1 graphic file with name 41419_2023_5930_Tabe_HTML.gif GPX4 and system XC— Nude mice; MDA-MB-231, Hs578T, and A549 cell lines Breast cancer, lung squamous cell carcinoma [136] Preclinical
PdPT graphic file with name 41419_2023_5930_Tabf_HTML.gif GPX4 Nude mice; A549 and NCI-H1299 cell lines Nonsmall cell lung cancer [137] Preclinical
Lidocaine graphic file with name 41419_2023_5930_Tabg_HTML.gif SLC7A11 Patient tumor tissues; nude mice; SKOV-3 and T47D cell lines Ovarian and breast cancer [138] Preclinical
Ketamine graphic file with name 41419_2023_5930_Tabh_HTML.gif GPX4 Patient tumor tissues; BALB/c nude mice; HepG2 and Huh7 cell lines Liver cancer [67] Approved
MMRi62 graphic file with name 41419_2023_5930_Tabi_HTML.gif P53 Patient tumor tissues, Panc1, BxPc3, panc10.05, AsPc1, Capan2, and SW1990 cell lines Pancreatic cancer [141] Preclinical
Bupivacaine graphic file with name 41419_2023_5930_Tabj_HTML.gif GPX4 and SLC7A11 Nude mice; T24 and 5637 cell lines Bladder cancer [139] Approved
6-Gingerol (natural) graphic file with name 41419_2023_5930_Tabk_HTML.gif USP14 and GPX4 Nude mice; A549 cell line Lung cancer [94] Preclinical
DMOCPTL (natural) graphic file with name 41419_2023_5930_Tabl_HTML.gif GPX4 Bar b/c mice; MDAMB-231, SUM159, BT574, and 4T1 (mouse) cell lines Triple-negative breast cancer [146] Preclinical
Bufotalin (natural) graphic file with name 41419_2023_5930_Tabm_HTML.gif GPX4 BALB/c nude mice; A549 cell line Nonsmall cell lung cancer [147] Preclinical
Alloimpertorin (natural) graphic file with name 41419_2023_5930_Tabn_HTML.gif GPX4 and SLC7A11 MCF-10A, MDA-MB-231, and MCF-7 cell lines Breast cancer [149] Preclinical

GPX4 glutathione peroxidase 4, ROS reactive oxygen species, SLC7A11 solute carrier family 7 member 11, system XC—, cystine-glutamate antiporter, USP14 ubiquitin-specific protease 14.