Table 3.
Comparison of similarity score among the wild-type, − 530 Gγ (A>G), and − 533 to − 529 Gγ (-ATAAG) sequences using the online TFBIND program for prediction of GATA related transcription factors binding affinity.
| AC ID from TRANSFAC R.3.4 | Name of the binding factor | Consensus sequence | Wild type | − 530 Gγ (A>G) (this study) | − 533 to − 529 Gγ (-ATAAG)33 |
|---|---|---|---|---|---|
| M00075 V$GATA1_01 | GATA-1 (GATA-binding factor 1) | SNNGATNNNN | 0.805035 | 0.870188 | < 0.77 |
| M00126 V$GATA1_02 | GATA-1 (GATA-binding factor 1) | NNNNNGATANKGNN | 0.863125 | 0.875312 | < 0.77 |
| M00127 V$GATA1_03 | GATA-1 (GATA-binding factor 1) | RNSNNGATAANNGN | 0.788829 | < 0.78 | < 0.78 |
| M00128 V$GATA1_04 | GATA-1 (GATA-binding factor 1) | NNCWGATARNNNN | 0.865502 | 0.849877 | < 0.81 |
| M00076 V$GATA2_01 | GATA-2 (GATA-2; GATA-box binding factor 2; GATA2; NF-E1b (chick)) | NNNGATRNNN | 0.853406 | 0.904826 | < 0.78 |
| M00077 V$GATA3_01 | GATA-3 (GATA-binding factor 3) | NNGATARNG | 0.887461 | 0.915817 | < 0.82 |
| M00203 V$GATA_C | GATA-X (GATA binding site) | NGATAAGNMNN | 0.967071 | 0.924511 | < 0.83 |
S = C or G, W = A or T, R = A or G, Y = C or T, K = G or T, M = A or C, N = any base pair.