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. 2023 Jul 24;14:4448. doi: 10.1038/s41467-023-40242-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Overview of modular arrangements to synthesize distinct phenylpropene products via downstream enzyme promiscuity for diverse hydroxycinnamic acid pathway intermediates. A Use of complete forms of Modules I-III to produce eugenol. B Removal of COMT from Module II to direct flux to hydroxychavicol production. C Removal of Module II entirely to enable chavicol accumulation.