. 2023 Apr 13;45(4):857–863. doi: 10.1007/s11096-023-01568-y

Table 2.

Interactions of remimazolam and propofol combined with 0.1 µg/kg sufentanil, evaluated based on eyelash reflex inhibition

Remimazolam		Propofol		Coefficient sum	Expected value of additive action	Interaction coefficient
ED₅₀ coefficient	ED₅₀ (mg/kg)	ED₅₀ coefficient	ED₅₀ (mg/kg)	Coefficient sum	Expected value of additive action	Interaction coefficient
1	0.063 (0.055–0.072)	0	0	1	1	1
0	0	1	0.672 (0.606–0.732)	1	1	1
0.25	0.016	0.710	0.477 (0.416–0.539)	0.960	1	1.04
0.5	0.032	0.329	0.221 (0.198–0.244)	0.829	1	1.21
0.75	0.047	0.195	0.131 (0.114–0.145)	0.945	1	1.06

Interaction coefficient = 1/coefficient sum

Parentheses show the 95% confidence interval