Table 1.

Various quantitative FDG parameters on 3-D and 4-D PET analysis

Parameters	Estimation	Clinical advantages	Disadvantages
SUV	Uptake concentration (max, peak, or mean)	Well established	Only pixel uptake
MTV	Uptake volume	Prognostic value	Depend on threshold
TLG	Uptake volume × mean uptake	Prognostic value	Depend on threshold
Heterogeneity	Radiomic analysis (texture analysis etc.)	Treatment resistance	Sensitive to scanner performance and analysis method
Ki	Uptake slope (Patlak plot)	Metabolic parameter	Difficult to estimate Dynamic acquisition
DV	Distribution volume (Patlak plot)	?	Difficult to estimate Dynamic acquisition

SUV standardized uptake value, MTV metabolic tumor volume, TLG total lesion glycolysis