Table 1.

Parameter values

Parameter	Description	Value	References
R	Cell radius	10 μm	Typical value
$\mathrm{\Delta }R$	Linking range around cell	3 μm	–
$\dot{c}$	Contraction rate of stress fiber	0.1 μm/s	Choquet et al. (1997), Moore et al. (2010)
$k_{\text{SF}}$	Stiffness of stress fiber	1 kPa	Gavara and Chadwick (2016)
$\eta$	Viscosity (water)	1 mPas	–
E	Young’s Modulus of collagen fibers	1.1 MPa	Jansen et al. (2018)
$R_f$	Radius of collagen fibers	90 nm	Van Der Rijt et al. (2006)
$d_{\text{bs}}$	Binding spot distance on collagen fibers	50 nm	Selhuber-Unkel et al. (2010)
$k_{\text{on}}$	Association rate for integrin	0.1 $s^{-1}$	Elosegui-Artola et al. (2016)
$F_{\text{opt}}$	Force at which integrin lifetime is maximal	30 pN	Kong et al. (2009), Weng et al. (2016)
$T_0$	Lifetime of integrin at zero force	0.25 s	–
$T_{\text{opt}}$	Lifetime of integrin at $F_{\mathit{opt}}$	3 s	Kong et al. (2009), Weng et al. (2016)
${\sigma }_2$	Spread of Gaussian distribution	pN	Kong et al. (2009), Weng et al. (2016)
$N_{FA,max}$	Maximal number of focal adhesions per cell	65	Horzum et al. (2014), Kim and Wirtz (2013), Mason et al. (2019)
$N_{i,max}$	Maximal number of integrins per focal adhesion	20	Changede et al. (2015), Chenget al. (2020)
L	Edge length of RVE	50 μm	–
$\mathrm{\Delta }t$	Time step size	0.05 s	–