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. 2023 Mar 13;315(7):2035–2056. doi: 10.1007/s00403-023-02541-5

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — STRING network diagram of all ADAM, ADAMTS and ADAMTSL proteases with epidermal SNVs and/or epidermal and/or dermal differential RNA expression. Nodes linked by evidence, with medium confidence level of 0.4 (default STRING criteria). Further genes with strong links to the ADAM, ADAMTS and/or ADAMTSL proteins were also included (via STRING extended analysis); two of which were the ‘delta like canonical notch ligands’ (1 and 4); linking the ADAM, ADAMTS and ADAMTSL proteins, to notch signalin