Table 4.

Epidermal RNA sequencing: Hallmark gene sets with significant positive or negative enrichment on GSEA, listed by NES

Hallmark gene set	NES	FDR
Positively enriched sets
TNF-α signaling via NFkB	2.514	< 0.001
TGF-β signaling	2.006	0.001
IL-6/JAKSTAT3 signaling	1.961	0.001
IFNα response	1.942	0.001
Inflammatory response	1.874	0.002
Androgen response	1.821	0.002
Early estrogen response	1.800	0.003
Protein secretion	1.664	0.009
IFNγ response	1.591	0.014
Heme metabolism	1.564	0.016
KRAS signaling ↑	1.515	0.022
Complement	1.456	0.032
p53 pathway	1.451	0.031
Late estrogen response	1.438	0.032
Apoptosis	1.268	0.109
mTOR-C1 signaling	1.178	0.191
Negatively enriched sets
E2F targets	-2.596	< 0.001
G2M check point	-2.375	< 0.001
Myogenesis	-1.800	0.005
Epithelial to mesenchymal transition	-1.796	0.005
MYC targets-V2	-1.754	0.006
Angiogenesis	-1.732	0.006
KRAS signaling ↓	-1.724	0.006
MYC targets-V1	-1.671	0.010
Glycolysis	-1.606	0.017
Apical surface	-1.581	0.020
DNA repair	-1.580	0.018
Hedgehog signaling	-1.571	0.018
Spermatogenesis	-1.506	0.030
Hypoxia	-1.497	0.030
Wnt-β-catenin signaling	-1.424	0.054
Mitotic spindle	-1.298	0.141
Apical junction	-1.268	0.167
Coagulation	-1.267	0.159
Oxidative phosphorylation	-1.205	0.232
Xenobiotic metabolism	-1.189	0.245