Table 5.
Dermal RNA sequencing: Hallmark gene sets with significant positive or negative enrichment on GSEA, listed by NES
| Hallmark gene set | NES | FDR |
|---|---|---|
| Positively enriched sets | ||
| Bile acid metabolism | 1.617 | 0.095 |
| Adipogenesis | 1.699 | 0.098 |
| Epithelial to mesenchymal transition | 1.536 | 0.125 |
| Xenobiotic metabolism | 1.464 | 0.131 |
| Cholesterol metabolism | 1.389 | 0.136 |
| IFNγ response | 1.402 | 0.145 |
| Angiogenesis | 1.422 | 0.147 |
| IFNα response | 1.465 | 0.162 |
| Peroxisome | 1.292 | 0.227 |
| Negatively enriched sets | ||
| Androgen response | -1.760 | 0.052 |
| Oxidative phosphorylation | -1.675 | 0.071 |
| Early estrogen response | -1.539 | 0.071 |
| Protein secretion | -1.549 | 0.075 |
| MYC targets, V1 | -1.571 | 0.076 |
| KRAS signaling (down) | -1.574 | 0.094 |
| G2M checkpoint | -1.592 | 0.108 |
| Late estrogen response | -1.468 | 0.113 |