Table 6.
Dermal RNA sequencing: transcripts contributing to the three key selected positively enriched PANTHER GO-Slim Biological Processes (multicellular organism development, humoral immune response and positive regulation of lymphocyte activation) with significant upregulation
| Gene symbol | Description | FDR | Log2FC | Log2CPM |
|---|---|---|---|---|
| IGHG2 | Immunoglobulin heavy constant gamma 2 (G2m marker) | < 0.001 | 5.508 | 4.426 |
| IGHG1 | Immunoglobulin heavy constant gamma 1 (G1m marker) | < 0.001 | 5.162 | 7.118 |
| IGLC2 | Immunoglobulin lambda constant 2 | < 0.001 | 4.302 | 4.821 |
| IGHG4 | Immunoglobulin heavy constant gamma 4 (G4m marker) | 0.037 | 4.112 | 2.760 |
| IGHM | Immunoglobulin heavy constant mu | < 0.001 | 4.027 | 5.798 |
| IGHA1 | Immunoglobulin heavy constant alpha 1 | < 0.001 | 3.794 | 6.702 |
| IGLC3 | Immunoglobulin lambda constant 3 (Kern-Oz marker) | < 0.001 | 3.215 | 4.507 |
| IGHA2 | Immunoglobulin heavy constant alpha 2 (A2m marker) | < 0.001 | 2.927 | 4.098 |
| CXCL9 | C-X-C motif chemokine ligand 9 | < 0.001 | 2.709 | 3.880 |
| SULF1 | Sulfatase 1 | < 0.001 | 0.976 | 5.124 |
| WNT10B | Wnt family member 10B | 0.024 | 0.895 | 2.714 |
| WNT16 | Wnt family member 16 | 0.001 | 0.742 | 5.145 |
| COL14A1 | Collagen type XIV alpha 1 chain | 0.003 | 0.723 | 7.332 |
| TENM4 | Teneurin transmembrane protein 4 | 0.032 | 0.668 | 5.754 |
| JCAD | Junctional cadherin 5 associated | 0.028 | 0.655 | 6.112 |
| NREP | Neuronal regeneration related protein | 0.017 | 0.613 | 5.547 |
| WNT2B | Wnt family member 2B | 0.048 | 0.576 | 5.703 |
| SULF2 | Sulfatase 2 | 0.006 | 0.546 | 7.069 |