Fig. 2.

Detection of anti-integrin αvβ6 autoantibodies in sera from patients with PSC. Serum IgG antibodies against integrin αvβ6 were quantified by an ELISA. The cutoff OD, defined as the mean plus three standard deviations of the healthy control sera, is indicated by a dashed line. a A validation group comprising 38 patients with PSC, 118 disease controls, and 20 healthy controls (Table S1) was examined. b Patients and controls from the screening and validation groups were examined. c Patients with PSC with or without IBD were examined. PSC primary sclerosing cholangitis, IgG immunoglobulin G, ELISA enzyme-linked immunosorbent assay, OD optical density, CCC cholangiocellular carcinoma, IgG4-SC IgG4-related sclerosing cholangitis, AIH autoimmune hepatitis, PBC primary biliary cholangitis