Fig. 3.

IgG subclasses and isotypes of the anti-integrin αvβ6 antibodies in sera from patients with PSC. a IgG subclasses of the anti-integrin αvβ6 antibodies were quantified by an ELISA. The cutoff OD, defined as the mean plus three standard deviations of the control sera, is indicated by a dashed line. Thirty (81.1%), 8 (21.6%), 5 (13.5%), and 4 (10.8%) of the 37 patients with PSC had IgG1, IgG2, IgG3, and IgG4 antibodies, respectively. Conversely, 1, 1, 0, and 1 of the 16 controls had IgG1, IgG2, IgG3, and IgG4 antibodies, respectively. b Isotypes of anti-integrin αvβ6 antibodies were quantified by ELISA. Twenty-one (56.8%), 0 (0%), and 4 (10.8%) of the 37 patients with PSC had IgA, IgM, and IgE antibodies against integrin αvβ6, respectively. Conversely, none of the 16 controls had IgA, IgM, or IgE antibodies. IgG immunoglobulin G, PSC primary sclerosing cholangitis, ELISA enzyme-linked immunosorbent assay, OD optical density