Table 5.
Clinical trials on the usage of CM in the treatment/support of OA registered in the ClinicalTrials.gov database
| Study number | Study Title | Summary | Status | Estimated Completion Date |
|---|---|---|---|---|
| NCT05579665 | Effectiveness of PRP, Conditioned Medium UC-MSCs Secretome and Hyaluronic Acid for the Treatment of Knee Osteoarthritis | Comparison of the efficacy of PRP, UC-MSCs-CM or HA injections in the treatment of knee osteoarthritis | Active, not recruiting | May 31, 2023 |
| NCT04314661 | Mesenchymal Stem Cell Therapy (MSCs) and Conditioned Medium Therapy for Osteoarthritis (OA) | Comparison of the efficacy of UC-MSCs and secretome between arthroscopy and without arthroscopy intervention in OA patients | Recruiting | December 8, 2024 |
| NCT04223622 | Effects of ASC Secretome on Human Osteochondral Explants (ASC-OA) | Investigation of the therapeutic potential of ASC secretome (conditioned medium or extracellular vesicles) on osteochondral explants – a more representative OA model of the physiological situation | Recruiting | December 2022 |
| NCT05060107 | Intra-articular Injection of MSC-derived Exosomes in Knee Osteoarthritis (ExoOA-1) (ExoOA-1) | The estimation of safety and outcome after a single injection of exosomes derived from allogenic MSC on the functionality of the patients affected with a moderate stage of advances of knee OA | Not yet recruiting | October 5, 2023 |
| NCT04225481 | Evaluation of Enhanced Therapeutic Effect of Adipose Stromal Vascular Fraction Added With Human Platelet Lysate in Treatment of Osteoarthritis | Investigating the effect of adipose tissue-derived-SVF enriched with human platelet lysate and CM isolated from them on OA chondrocytes | Unknown | July 2022 |
| NCT03800810 | Implantation of Allogenic Mesenchymal Stem Cell From Umbilical Cord Blood for Osteoarthritis Management | Comparison of the efficacy of UC-MSC in CM, HA and recombinant human somatropin intraarticular injections in patients with OA | Unknown | May 2019 |
ASC adipose stromal cells, CM conditioned medium, HA hyaluronic acid, MSC mesenchymal stromal cells, OA osteoarthritis, PRP platelet-rich plasma, SVF stromal vascular fraction, UC-MSCs Umbilical Cord MSCs