Table 2:
Mixed Model Results for Change in Overnight (21:00–11:00) CSF and Plasma Aβ, Tau, Phosphorylated Tau, and Albumin from Baseline
| CSF | |||||
|---|---|---|---|---|---|
| Biomarker | Factor | Pairwise Comparison | Mean Difference (95% CI) | F (df) | p |
| Aβ40, % baseline | Intervention | Sleep-deprived vs. Control | +33.675 (24.480, 42.869) | 53.71 (1,59.00) | <0.001 |
| Time of day | 0.612 (7,59.00) | 0.743 | |||
| Intervention x time | 0.658 (7,59.00) | 0.706 | |||
| Aβ42, % baseline | Intervention | Sleep-deprived vs. Control | +37.406 (26.822, 47.989) | 50.02 (1,59.00) | <0.001 |
| Time of day | 0.525 (7,59.00) | 0.812 | |||
| Intervention x time | 0.983 (7,59.00) | 0.452 | |||
| T181, % baseline | Intervention | Sleep-deprived vs. Control | +40.499 (27.316, 53.683) | 37.76 (1,60.00) | <0.001 |
| Time of day | 1.34 (7,60.00) | 0.246 | |||
| Intervention x time | 0.863 (7,60.00) | 0.541 | |||
| T217, % baseline | Intervention | Sleep-deprived vs. Control | +45.995 (34.250, 57.740) | 61.37 (1,60.00) | <0.001 |
| Time of day | 1.54 (7,60.00) | 0.171 | |||
| Intervention x time | 1.13 (7,60.00) | 0.359 | |||
| pT181, % baseline | Intervention | Sleep-deprived vs. Control | +55.110 (40.003, 70.217) | 53.25 (1,60.00) | <0.001 |
| Time of day | 1.50 (7,60.00) | 0.186 | |||
| Intervention x time | 1.18 (7,60.00) | 0.328 | |||
| Albumin, % baseline | Intervention | Sleep-deprived vs. Control | −18.140 (−25.926, −10.353) | 21.71 (1,60.00) | <0.001 |
| Time of day | 1.56 (7,60.00) | 0.164 | |||
| Intervention x time | 0.495 (7,60.00) | 0.834 | |||
| Plasma | |||||
| Biomarker | Factor | Pairwise Comparison | Mean Difference (95% CI) | F (df) | p |
| Aβ40, % baseline | Intervention | Sleep-deprived vs. Control | −5.293 (−8.023, −2.563) | 15.04 (1,60.00) | <0.001 |
| Time of day | 4.01 (7,60.00) | 0.001 | |||
| Intervention x time | 1.48 (7,60.00) | 0.190 | |||
| Aβ42, % baseline | Intervention | Sleep-deprived vs. Control | −6.315 (−9.080, −3.550) | 20.87 (1,60.00) | <0.001 |
| Time of day | 2.68 (7,60.00) | 0.018 | |||
| Intervention x time | 0.805 (7,60.00) | 0.586 | |||
| T181, % baseline | Intervention | Sleep-deprived vs. Control | −11.351 (−16.386, −6.316) | 20.35 (1,59.03) | <0.001 |
| Time of day | 3.48 (7,59.03) | 0.003 | |||
| Intervention x time | 0.487 (7,59.03) | 0.840 | |||
| T217, % baseline | Intervention | Sleep-deprived vs. Control | −8.302 (−12.171, −4.434) | 18.43 (1,60.00) | <0.001 |
| Time of day | 2.77 (7,60.00) | 0.015 | |||
| Intervention x time | 0.578 (7,60.00) | 0.771 | |||
| pT181, % baseline | Intervention | Sleep-deprived vs. Control | −15.456 (−26.537, −4.375) | 7.79 (1,59.12) | 0.007 |
| Time of day | 1.61 (7,59.12) | 0.151 | |||
| Intervention x time | 0.269 (7,59.12) | 0.964 | |||
| Albumin, % baseline | Intervention | Sleep-deprived vs. Control | +8.612 (−4.740, 21.964) | 1.67 (1,57.16) | 0.202 |
| Time of day | 0.748 (7,57.10) | 0.633 | |||
| Intervention x time | 1.31 (7,57.10) | 0.264 | |||
CSF = cerebrospinal fluid; Aβ = amyloid-β; T181 = unphosphorylated tau-181; T217 = unphosphorylated tau-217; pT181 = phosphorylated tau-181; CI = confidence intervals; df = degrees of freedom