Table 3:

Mixed Model Results for Change in Overnight (21:00 – 11:00) CSF/Plasma Ratios of Aβ, Tau, Phosphorylated Tau, and Albumin from Baseline

CSF/Plasma Ratios
Biomarker	Factor	Pairwise Comparison	Mean Difference (95% CI)	F (df)	p
Aβ40, % baseline	Intervention	Sleep-deprived vs. Control	+44.577 (34.058, 55.097)	71.90 (1,59.00)	<0.001
	Time of day			2.48 (7,59.00)	0.027
	Intervention x time			0.689 (7,59.00)	0.681
Aβ42, % baseline	Intervention	Sleep-deprived vs. Control	+48.692 (35.615, 61.769)	55.51 (1,59.00)	<0.001
	Time of day			1.27 (7,59.00)	0.279
	Intervention x time			1.00 (7,59.00)	0.439
T181, % baseline	Intervention	Sleep-deprived vs. Control	+57.702 (39.331, 76.073)	39.50 (1,59.01)	<0.001
	Time of day			1.99 (7,59.01)	0.072
	Intervention x time			1.02 (7,59.01)	0.425
T217, % baseline	Intervention	Sleep-deprived vs. Control	+58.823 (43.968, 73.677)	62.74 (1,60.00)	<0.001
	Time of day			2.10 (7,60.00)	0.057
	Intervention x time			0.956 (7,60.00)	0.472
pT181, % baseline	Intervention	Sleep-deprived vs. Control	+81.160 (50.118, 112.203)	27.37 (1,59.02)	<0.001
	Time of day			1.66 (7,59.02)	0.138
	Intervention x time			0.687 (7,59.02)	0.683
Albumin, % baseline	Intervention	Sleep-deprived vs. Control	−32.397 (−50.410, −14.384)	12.97 (1,57.19)	<0.001
	Time of day			0.718 (7,57.15)	0.657
	Intervention x time			1.24 (7,57.15)	0.298

CSF = cerebrospinal fluid; Aβ = amyloid-β; T181 = unphosphorylated tau-181; T217 = unphosphorylated tau-217; pT181 = phosphorylated tau-181; CI = confidence intervals; df = degrees of freedom