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. Author manuscript; available in PMC: 2023 Oct 23.
Published in final edited form as: Cell Rep. 2023 Jan 25;42(2):112042. doi: 10.1016/j.celrep.2023.112042

Figure 7. Age-related changes in the presynaptic machinery translates to postmortem human cortex.

Figure 7.

(A and B) The experimental design and representative western blots showing SNARE protein levels in postmortem human cortex as a function of age.

(C, D, and H) Syt-1, CSPα, and Syt-7 levels reveal that these proteins significantly decrease with age; bars show mean ± SEM; n = 8; experiments were replicated using three distinct cortical samples from the same subjects; N = 3; p = 0.027 (Syt-1); p = 0.022 (CSPα); p < 0.001 (Syt-7); simple linear regression.

(E–G) Stx1a, Syb2, and SNAP25 quantification reveals no change in expression with age; bars show mean ± SEM; n = 8; experiments were replicated using three distinct cortical samples from the same subjects; N = 3; p = 0.302 (Stx1a); p = 0.806 (Syb2); p = 0.497 (SNAP25); simple linear regression. When the representative bands in the figures belong to different membranes or different lanes on the same membrane, they are separated by a blank space. When they are in the neighboring lanes, they are presented without a blank space. Significance levels are as follows: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001; ns, non-significance. See also Figure S4 and Table S1.