TABLE 1.
Clinical information of patients included in this study and summary of single‐cell RNA sequencing and spatial transcriptome data.
| Sample | Status | Gender | Age | Organisation type | Incidence of bladder cancer | Pathological type (high grade) | Notes | Operative method | scRNA‐seq/ST name | Cell counts | Spot counts | Batch |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bladder cancer 1 | Primary | Male | 65 | Bladder carcinoma tissues and para‐carcinoma tissues | Emerging cancer | High‐grade invasive urothelial carcinoma | High‐grade invasive urothelial carcinoma has severe local tissue compression | Partial cystectomy | BLSC1/ST1 | 14105 | 3544 | 1 |
| Bladder cancer 2 | Primary | Male | 70 | Bladder carcinoma tissues and para‐carcinoma tissues | Emerging cancer | High‐grade invasive urothelial carcinoma | High‐grade invasive urothelial carcinoma of the bladder with more eosinophil infiltration in the stroma | Laparoscopic radical cystectomy | BLSC2/ST2 | 10070 | 4134 | 2 |
| Bladder cancer 3 | Primary | Male | 77 | Bladder carcinoma tissues and para‐carcinoma tissues | Emerging cancer | High‐grade invasive urothelial carcinoma | High‐grade invasive urothelial carcinoma of the bladder, invading the muscularis propria | Laparoscopic radical cystectomy | BLSC3/ST3 | 10601 | 4271 | 3 |
| Bladder cancer 4 | Recurrent | Female | 55 | Bladder carcinoma tissues and para‐carcinoma tissues | Recurrent cancer | High‐grade invasive urothelial carcinoma | High‐grade papillary urothelial carcinoma of the bladder, invading the whole layer of the bladder, invading the myometrium, vascular and nerve invasion, and cancer invasion of the right ureter and ovary | Laparoscopic radical cystectomy | BLSC4/ST4 | 8002 | 4421 | 1 |
| Bladder cancer 5 | Recurrent | Female | 68 | Bladder carcinoma tissues and para‐carcinoma tissues | Recurrent cancer | High‐grade invasive urothelial carcinoma | High‐grade invasive urothelial carcinoma of the bladder, size 3.2 × 2.5 × 1.5 cm, infiltrating the whole layer of bladder wall, nerve (–), vessel (–), sending ureteral margin (–), immunohistochemistry: CK7 (+), CK20 (–), S100P (+), p53 (+), CD44 (+), CK5/6 (+), GATA3 (–), Ki‐67 (60%) | Laparoscopic radical cystectomy | BLSC5/ST5 | 6796 | 4589 | 2 |
| Bladder cancer 6 | Recurrent | Male | 77 | Bladder carcinoma tissues and para‐carcinoma tissues | Recurrent cancer | Poorly differentiated bladder adenocarcinoma | Poorly differentiated bladder adenocarcinoma, invading the muscularis propria | Partial cystectomy | BLSC6/ST6 | 10284 | 4518 | 3 |