Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Challenges for CAR T-cell Immunotherapy in Solid Tumors (1). heterogeneous expression of tumor-associated antigens (TAA), leading to the growth of antigen-negative tumor variants (2); inefficient trafficking of CAR T cells at tumor sites (3); a poorly metabolized tumor microenvironment, including immunosuppressive molecules and cells are present, which can lead to CAR T-cell exhaustion.
