Fig. 4.

GFAP, MOG, and CCL11 expression in the hippocampus tissue samples. Top: Mean values of GFAP, MOG and CCL11 expression in necropsies of COVID-19 patients and controls, measured with O.D. (Optical Density, mean gray value). Mann–Whitney-U test effect size is shown with “r” values. Black rhomb indicates mean value. Bottom: Images of hippocampus tissue sample of GFAP (green), MOG (white), and CCL11 (red) in patients and controls. Example of control tissue sample is shown in A, C, and E. Example of COVID-19 tissue sample is shown in B, D, and F. A′, B′, C′, D′, E′ and F′ represent image detail. Scale bar = 150 μm: A, B, C, D, E, and F; Scale bar = 75 μm: A′, B′, C′, D′, E′, and F′ (∗p < 0.001).