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. 2023 Jul 13;94:104705. doi: 10.1016/j.ebiom.2023.104705

Fig. 3.

Fig. 3

Enrichment of risky/safe targets in gene sets based on a comparison of CGE and OGE. (a) Sankey diagram showing the discrepancy of gene perturbation effects between cells and humans. The numbers of genes based on a comparison of CGE and OGE are shown. (b–e) Enrichment of risky/safe targets in each gene set (N2E, N2N, E2E, and E2N). Plots in red and blue boxes represent the enrichment of risky and safe targets, respectively. The histogram shows the expected numbers of risky/safe targets in each gene set for 1000 permutation tests. Arrows denote the observed number of risky and safe targets. The observed numbers of risky/safe targets (N) and statistical significance (P) are shown inside the parenthesis. Statistical significance was measured using a one-tailed test. The one-tailed test was performed with the observed and the expected numbers of the risky/safe targets for 1000 permutation tests in each gene set. CGE, cellular gene essentiality; OGE, organismal gene essentiality.