Fig. 4.
Association of the cells/humans discrepancy with drug withdrawal due to severe side effects. (a) Enrichment of withdrawn drugs with severe side effects among drugs associated with each gene set (N2E, N2N, E2E, and E2N). (b) Enrichment analyses were performed with withdrawn drugs classified by side effect class. (a–b) Each bar represents the enrichment (odds ratio [OR]) of withdrawn drugs among drugs associated with each gene set (Inf, infinite). The statistical significance of enrichment was analysed using Fisher's exact test. Asterisks denote statistical significance (∗∗∗P < 1.0 × 10−3; ∗∗P < 1.0 × 10−2; ∗P < 5.0 × 10−2; n.s: not significant).