Fig. 5.
Integration of drug target and chemical information to predict drug approval. (a) Components of drug target and chemical information for predicting drug approval. (b–c) Prediction performance of drug approvals using a combination of drug target and chemical information. The components of each information combination are represented with filled dots in the matrix. Statistical significance (P) associated with the difference in the AUPRCs and AUROCs was analysed using the Mann–Whitney U test. (d) Numbers of correctly predicted approved drugs. (e) Enrichment of correctly predicted approved drugs with various drug indications. Each drug was classified by the level 1 Anatomical Therapeutic Chemical (ATC) code. Statistical significance (P) associated with enrichment was analysed using a hypergeometric test. Asterisks denote the statistical significance of enrichment (∗P < 5.0 × 10−2). CGE, cellular gene essentiality; OGE, organismal gene essentiality.