Table 1.

Successfully predicted approved drugs using an independent test set.

Drug	Indication	First approval year	Predicted approval probability	CGE of drug	OGE of drug
Fosdenopterin	Metal Metabolism, Inborn Errors	2021	0.85	−1.9	1.2
Angiotensin	Cardiovascular diseases, septic shock	2017	0.98	−2.1	1.0
Vasopressin	Diabetes insipidus, Sepsis	2014	0.97	−1.9	1.0
Linaclotide	Irritable Bowel Syndrome, Constipation	2012	0.85	−2.0	0.9
Pasireotide	Acromegaly	2012	0.74	−2.3	0.9
Telaprevir	Virus diseases	2011	0.64	−2.0	1.2
Icatibant	Angioedemas, Hereditary	2011	0.62	−2.2	1.1
Belumosudil	Graft versus host disease	2021	0.34	−1.9	1.8

Predicted approval probabilities of recently approved drugs (after 2011) in an independent test set.

Newly added drugs in the updated version of the ChEMBL database (v30) were employed as an independent test set.

The successfully predicted approved drugs are presented in bold font.