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. Author manuscript; available in PMC: 2024 Apr 14.
Published in final edited form as: ACS Infect Dis. 2023 Mar 22;9(4):773–784. doi: 10.1021/acsinfecdis.2c00478

Figure. 5. Model of energy changes to fusion resulting from Serinc5-induced increase in membrane heterogeneity of the viral envelope.

Figure. 5.

The free energy change of intermediate steps (orange titles) along the fusion reaction is shown by the blue line. Proposed effects of Serinc5-induced alterations of membrane physical properties are listed in black near each intermediate state. Many of these properties are inter-related and are not easily disentangled. The effect of increased membrane heterogeneity on the contribution of line tension to the energetics of fusion is shown by the red dashed line.