Table 2.
Characteristics of studies that investigated genetic polymorphisms associated with osteoporosis or bone mineral density in Thailand.
| Studies | Subjects | Main findings |
|---|---|---|
| Ongphiphadhanakul et al., 2001 | 228 postmenopausal women recruited by advertising to have BMD screening at Ramathibodi Hospital, Bangkok | ERα gene (rs2228480) GG genotype associated with osteoporosis |
| Songpatanasilp et al., 2011 | 235 postmenopausal women enrolled from the Phramongkutklao Hospital, Bangkok | FDPS gene (rs2297480) polymorphism not associated with osteoporosis |
| Utennam et al., 2012 | 228 postmenopausal women recruited by advertising to have BMD screening at Ramathibodi Hospital, Bangkok | TGFβ-1 gene (rs1800470) CT and CC genotypes associated with decreased serum TGF-β1 levels, osteopenia and osteoporosis |
| Chupeerach et al., 2012 | 365 postmenopausal women attending the menopause clinic at Ramathibodi Hospital, Bangkok | DBP gene (rs4588) CC genotype associated with higher risk of radial BMD osteoporosis |
| Tongboonchoo et al., 2013 | 346 postmenopausal women attending the menopause clinic at Ramathibodi Hospital, Bangkok | MTHFR gene (rs1801133) CT genotype associated with osteopenia and osteoporosis |
| Chupeerach et al., 2014 | 160 postmenopausal women attending the menopause clinic at Ramathibodi Hospital, Bangkok | ID4 gene (rs3798339) TT genotype associated with lower BMD |
| Sritara et al., 2014 | 1741 healthy workers from the Electricity Generating Authority of Thailand cohort | ASHG gene (rs2248690) polymorphism associated with BMD through fetuin-A and body mass index. |
| Kitjaroentham et al., 2016 | 277 postmenopausal women attending the menopause clinic at Ramathibodi Hospital, Bangkok | LRP5 gene polymorphisms not associated with osteoporosis |
| Techapatiphandee et al., 2018 | 237 postmenopausal women (105 with osteoporosiss) recruited from Thammasat Hospital, Pathum Thani, and Ramathibodi Hospital, Bangkok |
VDR gene (rs2228570) TT genotype associated with osteoporosis TNFSF11 gene polymorphisms not associated with osteoporosis |
| Wajanavisit et al., 2015 | 66 postmenopausal women with hip fracture who underwent hip surgery at the Department of Orthopedics, Ramathibodi Hospital, Bangkok | ERα gene (rs2228480) GG genotype associated with osteoporosis |
ASHG. α2 Heremans–Schmid glycoprotein; BMD, Bone mineral density; DBP: Vitamin D-binding protein; ERα, Estrogen receptor α; FDPS: Farnesyl pyrophosphate synthase, ID4: Inhibitor of DNA binding 4, LRP5, Low-density lipoprotein receptor related protein 5; MTHFR, Methylenetetrahydrofolate reductase; TGFβ-1, transforming growth factor-beta-1; TNFSF11, Tumor Necrosis Factor Superfamily Member 11.