Table 1.
Comparison of demographic and biochemical parameters between Graves’ disease (N = 50) and healthy controls (n-50).
| Parameter | Graves' disease (N = 50) | Healthy controls (N = 50) | P-value |
|---|---|---|---|
| Age, yr | 31.9 ± 10.9 | 31.2 ± 4.9 | P = 0.640 |
| Sex, F:M | 31:19 | 31:19 | |
| BMI, kg/m2 (N: 18.5–24.9) | 20.8 ± 4.0 | 25.7 ± 4.4 | P < 0.001 |
| Serum Ca, mmol/L (N: 2.1–2.6) | 2.3 ± 0.2 | 2.3 ± 0.1 | P = 0.067 |
| Serum PO4, mmol/L (N: 0.8–1.4) | 1.4 ± 0.3 | 1.1 ± 0.2 | P < 0.001 |
| Serum ALP, IU/L (N: 80–240) | 436. 5(IQR 307.7–574.0) | 220. 0 (181.5–288.5) | P < 0.001 |
| Serum 25(OH)D, nmol/L (N:50–125) | 45.4 (IQR 35.2–67.6) | 35.9 (IQR 24.7–47.9) | P = 0.074 |
| Serum iPTH, pmol/L (N: 1.6–6.9) | 4.9 (IQR 2.6–6.7) | 5.2 (IQR 3.6–6.8) | P = 0.378 |
| Serum T4, nmol/L (N:65.6–181.5) | 240.7 ± 63.1 | 104.3 ± 20.5 | P < 0.001 |
| Serum FT4, pmol/L (N:11.9–21.8) | 60. 4 (IQR 37.3–99.1) | 15.6 (IQR 12.1–20.1) | P < 0.001 |
| Serum T3, nmol/L (N:1.2–3.1) | 5.9 ± 2.4 | 1.6 ± 1.2 | P < 0.001 |
| Serum FT3, pmol/L (N:3.1–6.7) | 21.3 (IQR 9.6–30.5) | 4.6 (IQR 3.6–5.9) | P < 0.001 |
| Serum TSH, mIU/L (N:0.4–4.2) | <0.001 | 3.3 ± 0.2 | |
| Serum T Bil, μmol/L (N: 5.1–17.1) | 10.2 (IQR 6.8–15.3) | 8.5 (IQR 6.4–10.2) | P = 0.022 |
| Serum ALT (SGPT), IU/L (N: 4–36) | 34.0 (IQR 22.0–59.0) | 24.0 (IQR 15.0–33.7) | P = 0.002 |
| Serum AST (SGOT), IU/L (N: 8–33) | 33.0 (IQR 23.0–45.0) | 24.0 (IQR 18.7–29.2) | P = 0.001 |
| Serum urea, mmol/L (N: 1.8–7.1) | 3.6 (IQR 2.6–4.8) | 3.5 (IQR 2.9–3.8) | P = 0.332 |
| Serum creatinine, μmol/L (N: 53.0–97.2) | 44.2 (IQR 35.3–53.0) | 61.8 (IQR 53.0–70.7) | P < 0.001 |
| Serum T protein, g/L (N: 60.0–83.0) | 73.0 (IQR 70.5–76.2) | 75.5 (IQR 72.0–77.2) | P = 0.019 |
| Serum albumin, g/L (N:35.0–50.0) | 45.0 (IQR 40.0–49.0) | 48.0 (IQR 46.0–50.2) | P = 0.001 |
Data are expressed as mean ± standard deviation or median [Interquartile range (IQR)].
BMI, body mass index;, Ca, calcium; PO4, phosphorus; ALP, alkaline phosphatase; 25(OH)D-25-hydroxy-vitamin D; iPTH, intact parathyroid hormone; T4, thyroxine; FT4, free thyroxine; T3, tri-iodothyronine; FT3, free tri-iodothyronine; TSH, thyroid stimulating hormone; T Bil, total bilirubin; ALT, alanine transaminase; AST, aspartate transaminase.