Table 3.
Univariate and multivariate linear regression models predicting TBS in Graves’ disease and healthy controls.
| Univariate analysis |
Multivariate analysis |
|||
|---|---|---|---|---|
| Beta regression coefficient (β) (CI) | Univariate p | Beta regression coefficient (β) (CI) | Multivariate p | |
| Age | −0.213 (−0.005-0.000) | P = 0.033 | −0.092 (−0.003- 0.000) | P = 0.165 |
| BMI | 0.275 (0.002–0.010) | P = 0.006 | −0.120 (−0.006-0.001) | P = 0.127 |
| Serum T4 | −0.554 (−0.012–−0.006) | P < 0.001 | −0.356 (−0.009–−0.003) | P = 0.001 |
| Serum FT4 | −0.215 (−0.023- 0.004) | P = 0.161 | ||
| Serum T3 | −0.218 (−0.033- 0.005) | P = 0.145 | ||
| Serum FT3 | −0.147 (−0.06- 0.002) | P = 0.401 | ||
| Serum TSH | 0.314 (0.006–0.023) | P = 0.002 | −0.113 (−0.012-0.002) | P = 0.157 |
| 25(OH)D | −0.118 (−0.003- 0.001) | P = 0.328 | ||
| iPTH | −0.027 (−0.001- 0.000) | P = 0.830 | ||
| L1-L4 BMD | 0.733 (0.445–0.649) | P < 0.001 | 0.545 (0.260–0.553) | P < 0.001 |
| FN BMD | 0.619 (0.380–0.638) | P < 0.001 | 0.053 (−0.220-0.309) | P = 0.741 |
| TH BMD | 0.651 (0.389–0.626) | P < 0.001 | 0.061 (−0.249-0.344) | P = 0.752 |
| DR BMD | 0.555 (0.358–0.665) | P < 0.001 | 0.058 (−0.114-0.220) | P = 0.529 |
Data are expressed as beta regression coefficient (β), with 95% confidence interval (CI).
BMI, body mass index; T4, thyroxine; FT4-free thyroxine; T3, tri-iodothyronine; FT3, free tri-iodothyronine; TSH, thyroid stimulating hormone; 25(OH)D, 25-hydroxy-vitamin D; iPTH, intact parathyroid hormone; BMD, bone mineral density; TBS, trabecular bone score; L1-L4, lumbar spine; FN, femoral neck; TH, total hip; DR, distal radius.