Table 3.
Multivariable associations with statin use in secondary prevention individual (n = 34,934).
| Secondary prevention individuals using statins (N = 2332)a | Secondary prevention individuals not using statins (N = 32,602)a | OR (95% CI) | p-value | |
|---|---|---|---|---|
| Age group (vs. <60 years) | ||||
| ≥60 years | 1793 (76.9%) | 22,645 (69.5%) | 1.32 [1.19–1.47] | <0.0001 |
| Ethnicity/SDI (vs. Caucasian and Not High) | ||||
| Caucasian∗high | 430 (18.4%) | 4877 (15.0%) | 1.00 [0.86–1.16] | >0.95 |
| Non-caucasianb,∗ not high | 995 (42.7%) | 15,147 (46.5%) | 0.78 [0.69–0.88] | <0.001 |
| Non-caucasianb,∗ high | 434 (18.6%) | 7989 (24.5%) | 0.85 [0.73–0.98] | 0.031 |
| Gender (vs. Female) | ||||
| Male | 1200 (51.5%) | 16,103 (49.4%) | 1.08 [0.99–1.18] | 0.091 |
| Geographic region (vs. North) | ||||
| South | 275 (11.8%) | 1878 (5.8%) | 4.53 [3.66–5.60] | <0.001 |
| Northeast | 1359 (58.3%) | 15,616 (47.9%) | 3.13 [2.66–3.71] | <0.001 |
| Southeast | 453 (19.4%) | 7155 (21.9%) | 2.29 [1.91–2.76] | <0.001 |
| Midwest | 70 (3.0%) | 1025 (3.1%) | 2.48 [1.84–3.30] | <0.001 |
| Household location (vs. Rural Zone) | ||||
| Urban area | 1749 (75.0%) | 25,738 (78.9%) | 0.85 [0.77–0.95] | 0.0003 |
| Sedentary lifestyle (vs. No) | ||||
| Yes | 2181 (93.5%) | 31,256 (95.9%) | 0.64 [0.54–0.78] | <0.0001 |
| Smoking (vs. No) | ||||
| Yes | 252 (10.8%) | 4023 (12.3%) | 0.86 [0.75–0.99] | 0.042 |
| Use of antihypertensives (vs. No) | ||||
| Yes | 220 (9.4%) | 577 (1.8%) | 5.47 [4.60–6.47] | <0.001 |
| Stroke (vs. No) | ||||
| Yes | 1429 (61.3%) | 24,394 (74.8%) | 0.91 [0.78–1.07] | 0.30 |
| Myocardial infarction (vs. No) | ||||
| Yes | 1130 (48.5%) | 10,420 (32.0%) | 1.58 [1.35–1.85] | <0.0001 |
| Heart failure (vs. No) | ||||
| Yes | 337 (14.5%) | 2664 (8.2%) | 1.29 [1.13–1.47] | <0.0001 |
| Diabetes (vs. No) | ||||
| Yes | 946 (40.6%) | 9241 (28.3%) | 1.50 [1.37–1.64] | <0.0001 |
| Dyslipidaemia | ||||
| Yes | 371 (15.9%) | 1800 (5.5%) | 2.90 [2.55–3.29] | <0.0001 |
| Respiratory diseases (vs. No) | ||||
| Yes | 144 (6.2%) | 1761 (5.4%) | 0.95 [0.79–1.14] | 0.60 |
| Chronic kidney disease (vs. No) | ||||
| Yes | 214 (9.2%) | 2004 (6.1%) | 1.27 [1.08–1.48] | 0.0003 |
Acronyms and Abbreviations: OR, Odds ratio; CI, Confidence interval.
Area under the curve for the model (95% CI): 0.72 [0.71–0.73].
a
Reflects the actual sample size with complete data for the included variables.
b
Non-Caucasian includes people from Brown, Black and Yellow Ethnicity.