Table 4.
Multivariable associations with use of high dose statins in secondary prevention individuals (n = 34,934).
| Secondary prevention individuals using high-dose statins (N = 210)a | Secondary prevention individuals not using high-dose statins (N = 34,724)a | OR (95% CI) | p-value | |
|---|---|---|---|---|
| Age group (vs. <60 years) | ||||
| ≥60 years | 159 (75.7%) | 24,279 (69.9%) | 1.17 [0.85–1.63] | 0.30 |
| Ethnicity/SDI (vs. Caucasian and Not High) | ||||
| Caucasian∗high | 47 (22.4%) | 5260 (15.1%) | 1.29 [0.82–2.05] | 0.30 |
| -Not caucasianb,∗ not high | 90 (42.9%) | 16,052 (46.2%) | 0.91 [0.62–1.36] | 0.60 |
| Not caucasianb,∗ high | 32 (15.2%) | 8391 (24.2%) | 0.85 [0.52–1.39] | 0.50 |
| Gender (vs. Female) | ||||
| Male | 131 (62.4%) | 17,172 (49.5%) | 1.59 [1.20–2.12] | 0.0001 |
| Geographic region (vs. North) | ||||
| South | 26 (12.4%) | 2127 (6.1%) | 6.71 [3.05–16.4] | <0.0001 |
| Northeast | 126 (60.0%) | 16,849 (48.5%) | 5.29 [2.72–11.9] | <0.0001 |
| Southeast | 49 (23.3%) | 7559 (21.8%) | 4.59 [2.26–10.6] | <0.0001 |
| Midwest | 1 (0.5%) | 1094 (3.2%) | 0.64 [0.03–3.51] | 0.70 |
| Household location (vs. Rural Zone) | ||||
| Urban area | 153 (72.9%) | 27,334 (78.7%) | 0.76 [0.55–1.06] | 0.10 |
| Sedentary lifestyle (vs. No) | ||||
| Yes | 192 (91.4%) | 33,245 (95.7%) | 0.53 [0.33–0.90] | 0.012 |
| Smoking (vs. No) | ||||
| Yes | 15 (7.1%) | 4260 (12.3%) | 0.51 [0.29–0.84] | 0.014 |
| Use of antihypertensives (vs. No) | ||||
| Yes | 26 (12.4%) | 771 (2.2%) | 5.39 [3.43–8.16] | <0.0001 |
| Stroke (vs. No) | ||||
| Yes | 94 (44.8%) | 25,729 (74.1%) | 0.72 [0.44–1.12] | 0.20 |
| Myocardial infarction (vs. No) | ||||
| Yes | 138 (65.7%) | 11,412 (32.9%) | 2.38 [1.42–3.84] | <0.0001 |
| Heart failure (vs. No) | ||||
| Yes | 41 (19.5%) | 2960 (8.5%) | 1.40 [0.96–1.99] | 0.073 |
| Diabetes (vs. No) | ||||
| Yes | 89 (42.4%) | 10,098 (29.1%) | 1.51 [1.13–2.01] | 0.005 |
| Dyslipidaemia (vs. No) | ||||
| Yes | 39 (18.6%) | 2132 (6.1%) | 2.87 [1.97–4.08] | <0.0001 |
| Respiratory diseases (vs. No) | ||||
| Yes | 11 (5.2%) | 1894 (5.5%) | 0.78 [0.40–1.39] | 0.40 |
| Chronic kidney disease (vs. No) | ||||
| Yes | 19 (9.0%) | 2199 (6.3%) | 1.08 [0.64–1.72] | 0.80 |
Acronyms and Abbreviations: OR =Odds ratio; CI = Confidence interval.
Area under the curve for the model (95% CI): 0.81 [0.78, 0.83].
a
Reflects the actual sample size with complete data on the included variables.
b
Non-Caucasian includes people from Brown, Black and Yellow Ethnicity.