FIGURE 1.

Schematic of study workflow for remote data collection using tVNS and cognitive testing. Participant screening is conducted via automated self-scoring surveys. Eligible participants are screened a second time for safety by study staff and then consented into the study if eligible, through a combination of video teleconference (e.g., verbal consent) or teleconference plus email (if a digital signed consent is required). Stimulators are then mailed to participants, and in a video teleconference session study staff trains the participant on how to wear the stimulator and complete the browser-based cognitive battery. Depending on study complexity, subsequent sessions may involve more videoconference sessions with study staff while participants complete the study procedures, or for simpler designs participants could be asked to video or photograph their stimulator placement independently and upload it to share with study staff and then complete the cognitive testing independently.