Skip to main content
. 2023 Jun 27;26(7):107217. doi: 10.1016/j.isci.2023.107217

Figure 2.

Figure 2

Upregulation of Lipocalin 2 following S. epidermidis and co-localization with blood vessels

(A and B) Hippocampal protein and (B) mRNA expression of lcn2 24 h after induction of S. epidermidis infection (saline n = 5, S. epidermidis n = 5).

(C) Blood Lcn2 protein concentration 24 h after S. epidermidis infection (saline n = 9, S. epidermidis n = 10).

(D) Images of brain sections immunostained with anti-lcn2 (green), anti-CD31 (vessels-red), anti-AQP4 (astrocytes end-feet-blue) antibodies and DAPI (nuclei-turquoise) in the hippocampus of saline mice (top panel) and S. epidermidis infected mice (bottom panel).

(E) Images of brain sections immunostained with anti-lcn2 (green), anti-CD31 (vessels-red), anti-GFAP (astrocytes-blue) antibodies and DAPI (nuclei-turquoise) in the hippocampus of saline mice (top panel) and S. epidermidis infected mice (bottom panel), see also Video S1. Data are presented as median, 10–90th percentile. Statistical comparison between the S. epidermidis and saline groups was performed using the non-parametric Mann-Whitney test. ∗∗∗p < 0.001.