Figure 6.

Circulatory Lipocalin 2, CRP and cytokine levels in mice and preterm infants

(A) Correlation matrix of blood Lcn2 and chemokines and cytokine protein levels in PND5 mice 24 h after S. epidermidis infection (saline n = 9, S. epidermidis n = 10).

(B) Spearman correlations between serum lcn2 and cytokines and chemokine in preterm infant blood. Spearman’s rank correlation coefficient is shown in the heatmap. P-value 0.05, 0.01 and 0.001 are indicated with ∗, ∗∗, ∗∗∗ respectively.

(C) Venn diagram showing the overlap between cytokines significantly correlated with lcn2 in mouse and preterm infants on postnatal days 7 and 14.

(D) Correlation of the common cytokines between human and mouse with lcn2 on postnatal days 7 and 14. Lcn2 data are presented as Normalized Protein expression (NPX). The correlation coefficient between two variables is presented in the graphs.