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. 2023 Jun 27;26(7):107217. doi: 10.1016/j.isci.2023.107217

Figure 7.

Figure 7

Differential protein expression and LCN2 identification in preterm infant blood

(A) Heatmap of differentially expressed proteins at day 7 (A, top panel) and day 14 (A, bottom panel).

(B) A total of 102 proteins were identified at day 7 and 52 proteins at day 14 to be differentially expressed between low and high CRP groups. The intersection of the significant proteins identified 33 proteins as proteins in common at both time points.

(C) Protein-protein interaction network constructed from the 33 common proteins. The network was created using Cytoscape software.

(D–H) Enrichment map of significantly gene ontology (GO) terms. Nodes represent gene sets. Highly similar protein sets are connected by edges, grouped in sub-clusters, and annotated automatically. LCN2 concentrations in blood of preterm infants at day 7 (n = 67 low CRP and n = 56 high CRP group) (E) and at day 14 (n = 42 low CRP and n = 49 high CRP group) (F). ROC curves of differentiating low CRP and high CRP group at day 7 (G) and day 14 (H). Data are presented as median, 10–90th percentile. Statistical comparison between S. epidermidis and saline for each group was performed using the non-parametric Mann-Whitney test. ∗p < 0.05; ∗∗p < 0.01. See also Table S5.