Figure 6.

Redistribution of histone acetylation at genome-wide level on TSA treatment in Min6 cells is associated with differential gene expression at transcriptome-wide level

(A) Volcano plot displaying downregulated (red circles), upregulated (green circles) and not deregulated genes (black circles) in TSA-treated cells compared to vehicle-treated cells according to two cut-off thresholds based on adjusted p value (Padj) and Log2 fold change (Log2FC).

(B and C) Ingenuity Pathway analysis (IPA) of downregulated (B) and upregulated (C) genes in Min6 cells on TSA treatment.

(D and E) Pie chart displaying proportion of TSA-dependent downregulated (D) and upregulated (E) genes in Min6 cells associated with a specific functional genomic region.

(F and G) Metascape analysis of genes with an active promoter that are downregulated (F) and upregulated (G) on TSA treatment.

See also Tables S1, S2, S3 and Figures S5 and S6.