Figure 8.
TSA treatment of the human β cell line EndoCβH1 and ex vivo human islets of Langerhans affects insulin secretion related pathways
(A and B) Schematic representation of EndoC-βH1 and human islets treatment by TSA and subsequent RNA-seq analysis.
(C) Volcano plot displaying downregulated (red circles), upregulated (green circles) and not deregulated genes (black circles) in EndoC-βH1 control and TSA-treated cells.
(D and E) Top 5 canonical pathways identified by IPA of downregulated (D) and upregulated (E) genes in TSA-treated EndoC-βH1 cells.
(F) Volcano plot displaying downregulated (red circles), upregulated (green circles) and not deregulated genes (black circles) in TSA-treated human islet compared to untreated controls.
(G and H) Top 5 canonical pathways identified by IPA of downregulated (D) and upregulated (E) genes in TSA-treated human pancreatic islets.