Table 2.
Selected variables by multivariable Cox regression analysis.
| Variable | Multivariable analysis | ||
|---|---|---|---|
| HR | 95% CI | P value | |
| Age at diagnosis | 1.033 | 1.023–1.043 | <0.001 |
| Bone metastasis | |||
| No | Reference | ||
| Yes | 2.758 | 1.300–5.852 | <0.01 |
| Brain metastasis | |||
| No | Reference | ||
| Yes | 2.517 | 1.108–5.72 | <0.05 |
| Liver metastasis | |||
| No | Reference | ||
| Yes | 4.203 | 2.035–8.679 | <0.001 |
| Stage | |||
| Localized | Reference | ||
| Regional | 2.202 | 1.263–3.837 | <0.01 |
| Distant | 3.904 | 1.697–8.981 | <0.01 |
| AJCC | |||
| I | Reference | ||
| II | 1.753 | 1.086–2.831 | <0.05 |
| III | 2.941 | 1.492–5.798 | <0.01 |
| IV | 3.197 | 1.149–8.895 | <0.05 |
| Primary site | |||
| Skin of upper limb and shoulder | Reference | ||
| Skin of trunk | 1.563 | 1.132–2.158 | <0.01 |
| Skin of scalp and neck | 1.767 | 1.223–2.555 | <0.01 |
| Histologic subtype | |||
| LMM | Reference | ||
| SSM | 0.966 | 0.500–1.869 | 0.919 |
| NM | 1.491 | 0.760–2.925 | 0.245 |
| AM | 2.671 | 1.005–7.097 | <0.05 |
| Ulceration | |||
| No | Reference | ||
| Yes | 1.525 | 1.153–2.016 | <0.01 |
NM, Nodular melanoma; LMM, Lentigo maligna melanoma; SSM, Superficial spreading melanoma; AM, Acral melanoma.