Figure 5.

Effects of Ca-EDTA, aztreonam and ceftazidime/avibactam and their combination on bacteremia

Effects of PBS (control), aztreonam (700 mg/kg), ceftazidime/avibactam (375 mg/kg), ceftazidime-avibactam + aztreonam (375 mg/kg + 700 mg/kg), Ca-EDTA (80 mg/kg/day), aztreonam -Ca-EDTA (700 mg/kg + 80 mg/kg/day) and ceftazidime/avibactam- Ca-EDTA (375 mg/kg + 80 mg/kg/day) on carbapenemase-producing K. pneumoniae clinical isolates (n = 7) mouse bacteremia infection model (A) illustration of a mouse model, (B) bacterial load in internal organs, (C) survival of mice. p values were determined using a two-sided Mann–Whitney U-test. All data were presented as means ± s.d.