Figure 7.

Effects of Ca-EDTA, aztreonam and ceftazidime/avibactam and their combination on thigh infection

Effects of PBS (control), aztreonam (700 mg/kg), ceftazidime/avibactam (375 mg/kg), ceftazidime-avibactam + Aztreonam (375 mg/kg + 700 mg/kg), Ca-EDTA (80 mg/kg/day), aztreonam -Ca-EDTA (700 mg/kg + 80 mg/kg/day) and ceftazidime/avibactam- Ca-EDTA (375 mg/kg + 80 mg/kg/day) on carbapenemase-producing K. pneumoniae clinical isolates (n = 7) mouse thigh infection model (A) illustration of a mouse model, (B) bacterial load in thigh, (C) serum creatinine of mice (D) relative expression of virulence genes. p values were determined using a two-sided Mann–Whitney U-test. All data were presented as means ± s.d.