Table 2.
Multivariate logistic regression for the primary outcome of all‐cause mortality and the secondary outcomes of mechanical ventilation and vasopressor use among famotidine, pantoprazole, and nonuse groups
| Variable | All‐cause mortality OR (95% CI) | Mechanical ventilation OR (95% CI) | Vasopressor use OR (95% CI) |
|---|---|---|---|
| Treatment | |||
| None | 1.00 | 1.00 | 1.00 |
| Famotidine | 0.30 (0.20–0.44)*** | 0.93 (0.59–1.47) | 0.62 (0.41–0.95)* |
| Pantoprazole | 0.47 (0.33–0.66)*** | 2.53 (1.77, 3.64)*** | 1.94 (1.39, 2.71)*** |
| Age (years) | 1.08 (1.07, 1.09)*** | 1.01 (1.00–1.02) | 1.01 (1.004–1.02)** |
| Sex (female) | 0.91 (0.68–1.21) | 0.57 (0.42–0.78)*** | 1.14 (0.85–1.53) |
| Diabetes mellitus (yes) | 0.92 (0.69–1.24) | 1.32 (0.95–1.84) | 1.10 (0.81–1.49) |
| COPD (yes) | 0.94 (0.66–1.33) | 1.88 (1.29–2.74)** | 1.47 (1.02–2.11)* |
| Chronic kidney disease (yes) | 1.33 (0.93–1.88) | 1.10 (0.78–1.55) | 1.43 (1.04–1.96)* |
| Coronary artery disease (yes) | 0.86 (0.62–1.19) | 0.65 (0.45–0.95)* | 1.49 (1.06–2.10)* |
| Heart failure (yes) | 1.45 (1.03–2.04)* | 1.30 (0.87–1.95) | 0.91 (0.62–1.33) |
| Hypertension (yes) | 0.65 (0.43–0.97)* | 0.85 (0.56–1.28) | 1.07 (0.72–1.59) |
| Diarrhea (yes) | 1.37 (0.86–2.17) | 1.42 (0.87–2.31) | 0.95 (0.59–1.54) |
| Mechanical ventilation (yes) | 14.45 (9.83–21.91)*** | — | 26.15 (19.15–35.72)*** |
| Vasopressor use (yes) | 2.40 (1.66–3.47) | 26.18 (19.16–35.79)*** | — |
| Acute kidney injury (yes) | 3.42 (2.43–4.82)*** | — | — |
| Gastrointestinal bleeding (yes) | 1.47 (0.85–2.56) | — | — |
| Nagelkerke R 2 | 0.56 | 0.51 | 0.49 |
*
P <0.05;
**
P <0.01;
***
P <0.001.
Inspection of variance inflation factor values indicates no concerns of multicollinearity.
CI, confidence interval; COPD, chronic obstructive pulmonary disease; OR, odds ratio.