Table 4.
Multivariate logistic regression for the primary outcome of all‐cause mortality and the secondary outcomes of mechanical ventilation and vasopressor use between famotidine and pantoprazole
| Variable | All‐cause mortality OR (95% CI) | Mechanical ventilation OR (95% CI) | Vasopressor use OR (95% CI) |
|---|---|---|---|
| Treatment | |||
| Pantoprazole | 1.00 | 1.00 | 1.00 |
| Famotidine | 0.65 (0.45–0.95)* | 0.38 (0.25–0.58)*** | 0.33 (0.22–0.48)*** |
| Age (years) | 1.06 (1.05–1.08)*** | 0.99 (0.98–1.01) | 1.01 (1.00–1.02) |
| Sex (female) | 0.83 (0.59–1.18) | 0.72 (0.49–1.04) | 1.05 (0.73–1.51) |
| Diabetes mellitus (yes) | 1.04 (0.72–1.50) | 1.52 (1.02–2.26)* | 0.87 (0.60–1.28) |
| COPD (yes) | 0.83 (0.55–1.26) | 2.17 (1.40–3.38)** | 1.35 (0.88–2.07) |
| Chronic kidney disease (yes) | 1.39 (0.90–2.13) | 1.12 (0.73–1.70) | 1.79 (1.20–2.68)** |
| Coronary artery disease (yes) | 0.83 (0.57–1.21) | 0.79 (0.51–1.23) | 1.44 (0.96–2.16) |
| Heart failure (yes) | 1.63 (1.10–2.43)* | 1.37 (0.86–2.19) | 0.88 (0.57–1.38) |
| Hypertension (yes) | 0.69 (0.41–1.19) | 0.69 (0.41–1.16) | 1.45 (0.86–2.45) |
| Diarrhea (yes) | 1.62 (0.94–2.79) | 1.11 (0.61–2.01) | 0.97 (0.54–1.75) |
| Mechanical ventilation (yes) | 13.47 (8.30–21.86)*** | — | 30.60 (20.91–44.78)*** |
| Vasopressor use (yes) | 2.02 (1.30–3.14)** | 30.44 (20.78–44.60)*** | — |
| Acute kidney injury (yes) | 2.92 (1.90–4.49)*** | — | — |
| Gastrointestinal bleeding (yes) | 1.80 (0.98–3.29) | — | — |
| Nagelkerke R 2 | 0.56 | 0.55 | 0.55 |
*
P <0.05;
**
P <0.01;
***
P <0.001.
Inspection of variance inflation factor values indicates no concerns of multicollinearity.
CI, confidence interval; COPD, chronic obstructive pulmonary disease; OR, odds ratio.