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. 2023 Jul 3;26(7):107268. doi: 10.1016/j.isci.2023.107268

Figure 2.

Figure 2

QHRD106 protected against apoptosis and neuroinflammation via B2R during stroke

(A) Representative dual-immunofluorescence staining of NeuN (red)/TUNEL (green).

(B) The percentage of NeuN+TUNEL+ cells among all NeuN+ cells in the peri-infarct brain regions (n = 3/group; one-way ANOVA and Tukey’s post hoc test.

(C) Representative western blot images of Bax, Bcl-2, and β-actin expression in the ischemic penumbras of mice 3 days poststroke.

(D) Quantification of Bax/Bcl-2.

(E–H) Representative western blots and quantitative analysis of the proinflammatory cytokine levels of iNOS, MCP-1, and TNF-α in the ischemic penumbras of mice 3 days poststroke.

(I–N) The mRNA levels of Nos2, Ccl2, Tnfa, Il6, Il1b, and Il10 in the ischemic penumbras of MCAO mice 3 days poststroke were detected via quantitative real-time PCR.

All data are presented as the mean ± SEM. Statistical analyses were performed by one-way ANOVA followed by Tukey’s post hoc test. ∗p < 0.05, ∗∗p < 0.01 vs. the saline group; #p < 0.05, ##p < 0.01 vs. the QHRD106 group; “ns” indicates no significance (p > 0.05).