REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit anti-Bax	Bioworld	Cat#BS2538; RRID:AB_1663713
Rabbit anti-Bcl-2	Bioworld	Cat#BS1511; RRID:AB_1663933
Mouse anti-iNOS	BD Biosciences	Cat#610328; RRID:AB_397718
Mouse anti-MCP-1	Proteintech	Cat#66272-1-Ig; RRID:AB_2861337
Rabbit anti-TNF-α	Proteintech	Cat#17590-1-AP; RRID:AB_2271853
Rabbit anti-β-actin	Bioworld	Cat#AP0060; RRID:AB_2797445
Rabbit anti-Lamin B1	Bioworld	Cat#AP6001; RRID:AB_2797499
Rabbit anti-HMGB1	Abcam	Cat#ab18256; RRID:AB_444360
Rabbit anti-GAPDH	Bioworld	Cat#AP0063; RRID:AB_2651132
Rabbit anti-Acetyllysine	PTM-BioLab	Cat#PTM-105; RRID:AB_2877698
Rabbit anti-HSP90AA1	Invitrogen	Cat#PA3-013; RRID:AB_2120934
Mouse anti-HSP90AA1	Proteintech	Cat#60318-1-lg
Mouse anti-NeuN	Abcam	Cat#ab104224; RRID:AB_10711040
Goat anti-Iba-1	Abcam	Cat#ab5076; RRID:AB_2224402
Goat anti-rabbit IgG (H + L) secondary antibody, HRP	Bioworld	Cat#BS13278; RRID:AB_2773728
Goat anti-mouse IgG (H + L) secondary antibody, HRP	Bioworld	Cat#BS12478; RRID:AB_2773727
Donkey anti-goat, Alexa Fluor 488	Invitrogen	Cat#A11055; RRID:AB_2534102
Donkey anti-mouse, Alexa Fluor 488	Invitrogen	Cat#A21202; RRID:AB_141607
Donkey anti-rabbit, Alexa Fluor 594	Invitrogen	Cat#A21207; RRID:AB_141637
Donkey anti-mouse, Alexa Fluor 594	Invitrogen	Cat#A21203; RRID:AB_141633
Chemicals, peptides, and recombinant proteins
HOE-140	MedChemExpress	Cat#HY-17446
Geldanamycin	MedChemExpress	Cat#HY-15230
R-715	Tocris Bioscience	Cat#3407
LPS	Sigma-Aldrich	L6529
Deposited data
Proteomics analysis	N/A	Accession number: PXD042777
Interactome analysis	N/A	Accession number: PXD042778
Experimental models: Organisms/strains
Mouse: C57/BL6J	the Model Animal Research Center of Nanjing University	N/A
Oligonucleotides
Nos2	TsingkeBiotechnologyCo.,Ltd.	F:CAGCTGGGCTGTACAAACCTT R: CATTGGAAGTGAAGCGTTTCG
Il6	TsingkeBiotechnologyCo.,Ltd.	F:GCTGGTGACAACCACGGCCT R: AGCCTCCGACTTGTGAAGTGGT
Tnfa	TsingkeBiotechnologyCo.,Ltd.	F:CAAGGGACAAGGCTGCCCCG R:GCAGGGGCTCTTGACGGCAG
Ccl2	TsingkeBiotechnologyCo.,Ltd.	F: TTGAGGTGGTTGTGGAAAAGG R:GTGCTGACCCCAAGAAGGAAT
Il1b	TsingkeBiotechnologyCo.,Ltd.	F:AAGCCTCGTGCTGTCGGACC R:TGAGGCCCAAGGCCACAGG
Il10	TsingkeBiotechnologyCo.,Ltd.	F:GGTTGCCAAGCCTTATCGGA R:ACCTGCTCCACTGCCTTGCT
Gapdh	TsingkeBiotechnologyCo.,Ltd.	F:GCCAAGGCTGTGGGCAAGGT R:TCTCCAGGCGGCACGTCAGA
Software and algorithms
ImageJ	NIH	N/A
Prism	GraphPad	N/A
Adobe Illustrator CS6	Adobe Systems	N/A