图 4.

LRG1通过增强TGF-β1信号改善高脂饮食诱导的肝脏脂肪变性

LRG1 regulates HFD-induced MAFLD by enhancing TGF-β1 signaling. After feeding on HFD for 16 weeks, the mice were injected with LRG1 (50 μg/kg), TGF-β1 (500 ng/kg) or both through the caudal vein for 3 times (once/5 days). Liver tissues were collected for HE staining (A) and immumohistochemical staining for F4/80 (B) (black arrows indicate F4/80 + cells). C: Serum levels of AST, ALT, TC and TG in the mice. D: RT-qPCR for detecting mRNA expression levels of iNOS, CXCL-1 and IL-1β in the liver tissues. E: Intraperitoneal glucose tolerance test. Scale bar=20 μm. Data are presented as Mean±SE (n=6). *P < 0.05.