Figure S5. Difference in the position of the α4 helix between the zinc-bound (magenta) and cadmium-bound (orange) forms of the A. aeolicus MutL C-terminal endonuclease domain.

Val421 at the C-terminus of the α4 helix is shown as stick models. When the active site in one of the two subunits of the zinc-bound form was superimposed onto that of the cadmium-bound form, the distance between the Cα atoms of Val421 of the same subunit was 2.70 Å.