(A) Volcano plot of differentially expressed isoforms. Red dots indicate expression changes with adjusted P-value <0.05 and magnitude change >1.5. Gene names are ordered by top 10 most significantly altered isoforms. (B) Differential event overlap of isoforms from genes involved kappa-light-chain-enhancer of B cells signaling pathway. Each box indicates an isoform, where red signifies if a particular isoform resulted as significantly altered for the corresponding analysis. DIE, differential isoform expression; DIU, differential isoform usage; DGE, differential gene expression; SE, skipped exon; A3, alternative 3′ splice site usage; A5, alternative 5′ splice site usage; IR, intron retention; APA, alternative polyadenylation site usage. (C) Same as panel (B), except including all isoforms with altered expression or usage. Red arrow highlights UPP1 (gold bars).